Cura settings for CR-10

PLA Filament settings:

Layer height	0.04mm, 0.08mm, 0.12mm, 0.16mm, 0.2mm, 0.24mm, 0.26mm, 0.3mm
Wall thickness	1mm to 1.2mm
Outer wall wipe distance	3mm
Top/Bottom Distance	0.8mm
Z seam alignment	Sharpest corner
Seam corner preference	Smart hiding
Infill density	15% to 80%
Printing temperature	200
Build plate temperature	50
Enable retraction	True
Retraction distance	6.5mm
Retraction speed	25mm/s
Print speed	40mm/s
Infill speed	40mm/s
Wall speed	40mm/s
Outer wall speed	25mm/s
Inner wall speed	40mm/s
Top/Bottom speed	20mm/s
Travel speed	40mm/s
Initial layer speed	20mm/s
Combing mode	Not in Skin
Avoid printed parts while traveling	True
Travel avoid distance	0.625mm
Z hop while retracted	False
Enable print cooling	True
Fan speed	100%
Generate support	True/False
Support placement	Touching buildplate/Everywhere
Support overhang angle	30 to 80
Support pattern	Zig zag
Support density	20%
Enable support brim	True/False
Support brim width	8mm to 20mm
Support Z distance	0.16mm
Support top distance	0.16mm
Gradual support infill steps	0 to 3
Use towers	False
Build plate adhesion type	Brim
Brim width	10mm to 25mm
Union overlapping volumes	False
Tree support	False

TPU Filament Settings:

Layer height	0.04mm, 0.08mm, 0.12mm, 0.16mm, 0.2mm, 0.24mm, 0.26mm, 0.3mm
Wall thickness	1mm to 1.2mm
Outer wall wipe distance	3mm
Top/Bottom Distance	0.8mm
Z seam alignment	Sharpest corner
Seam corner preference	Smart hiding
Infill density	15% to 80%
Printing temperature	210
Build plate temperature	50
Enable retraction	True
Retraction distance	6.5mm
Retraction speed	25mm/s
Print speed	20mm/s
Infill speed	20mm/s
Wall speed	20mm/s
Outer wall speed	20mm/s
Inner wall speed	20mm/s
Top/Bottom speed	20mm/s
Travel speed	20mm/s
Initial layer speed	20mm/s
Combing mode	Not in Skin
Avoid printed parts while traveling	True
Travel avoid distance	0.625mm
Z hop while retracted	False
Enable print cooling	True
Fan speed	100%
Generate support	True/False
Support placement	Touching buildplate/Everywhere
Support overhang angle	30 to 80
Support pattern	Zig zag
Support density	20%
Enable support brim	True/False
Support brim width	8mm to 20mm
Support Z distance	0.16mm
Support top distance	0.16mm
Gradual support infill steps	0 to 3
Use towers	False
Build plate adhesion type	Brim
Brim width	10mm to 25mm
Union overlapping volumes	False
Tree support	False

Printer Setup:

The default extruder assembly is pretty bad, allowing for shifting of the extruder head, so I recommend replacing it.  I use an e3D V6 hotend with a silicone sock and Petsfang hotend assembly (modified to suit my needs) and a blower fan and Noctua fan for cooling.

I have an endoscope camera attached to my hotend assembly that allows me to monitor the hotend up close and has helped me immeasurably by helping me stop print errors as fast as possible.  It also helps me level my printer bed to achieve a good first layer and good build plate adhesion.  I have my endoscope hooked up to my tablet via USB for constant monitoring.  

I also use Octoprint/Octopi for Raspberry PI, allowing me to upload stl files via WIFI to my printer without running over with a SD card every time.  It also allows me to remotely monitor the current print’s progress via a webpage.  Cura has a plugin called Octoprint Connection on their marketplace (top right in Cura) for Octoprint, so you can directly upload to your printer after slicing.

Recently I built a humidity controlled box for my filament to improve printing results and it has made a world of difference for my TPU prints.

For build plate adhesion I use an Elmer's Glue stick.  If you end up using this, make sure you wash your build plate every now and then to keep it from building up and screwing up your first layer quality.

Since the CR-10 is pretty noisy, I use motor vibration dampers and a lower printing speed (20mm/s to 40mm/s) to reduce the noise to residential levels.  This has the added benefit of improving print quality.